Glioblastoma with primitive neuronal component: An immunohistochemical study and review of literature

Glioblastoma is the most common malignant brain tumour in adults, accounting for about 45–50% of all the primary brain neoplasms [1]. Histomorphology of this WHO grade IV neoplasm is highly variable with intratumoral and intertumoral heterogeneity. The 2016 WHO classification of tumors of the central nervous system recognized certain distinct morphological patterns of glioblastoma, which are: small cell glioblastoma, glioblastoma with primitive neuronal component and glioblastoma with oligodendroglioma component.