Overexpression of Hepatocyte growth factor and its soluble receptor (s-cMet) in the serum of patients with different grades of meningioma

Meningioma arises from the meningothelial cells that make up the arachnoid villi of the meninges. It is the most common brain tumor, accounting for 36.4% of all primary brain tumors in the USA [1]. It is more common in women than men [2]. According to the World Health Organization (WHO), meningiomas are categorized into 3 grades (grades I-III). Criteria include cell type, mitotic activity, cellularity, necrosis, and brain invasion. WHO grade I or benign, grade II (atypical) and grade III represent approximately 90%, 5%-7% and 3% of all meningiomas, respectively [3].