[Articles] Variant-dependent heterogeneity in amyloid ? burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study

Autosomal dominant Alzheimer's disease pathogenic variants showed highly differential temporal and regional patterns of PiB-PET signal, despite similar functional progression. These findings suggest that although increased PiB-PET signal is generally seen in autosomal dominant Alzheimer's disease, higher levels of PiB-PET signal at an individual level might not reflect more severe or more advanced disease. Our results have high relevance for ongoing clinical trials in autosomal dominant Alzheimer's disease, including those using A? PET as a surrogate marker of disease progression.