[Comment] Mesenchymal stem cells for multiple sclerosis: hype or hope?

In the search for new approaches to treat or even cure multiple sclerosis, several forms of cell-based therapies have been explored, including haematopoietic stem cells, mesenchymal stem cells, and oligodendrocyte progenitor cells.1 In the past 15 years, several small uncontrolled trials have assessed the safety and feasibility of approaches using mesenchymal stem cells derived from diverse tissues (eg, bone marrow, adipose tissue, or placenta), with different routes of administration (eg, intravenous or intrathecal), and various outcome measures (eg, clinical, neurophysiological, or MRI-based measures).