[Correspondence] Multiple sclerosis meets systems immunology

In their Review,1 Amit Bar-Or and Rui Li argue that autoimmune diseases like multiple sclerosis arise from perturbations of cellular networks, resulting in a disbalance of proinflammatory and anti-inflammatory mechanisms. Such a disbalance potentially enables both spontaneous stabilisation and exacerbation of disease activity, as observed in relapsing multiple sclerosis. The underlying immune processes are partly stochastic, yet shaped by a multitude of genetic and environmental influences.