Atypical antipsychotics in Multiple Sclerosis: a review of their in vivo immunomodulatory effects

Multiple sclerosis (MS) is an immune-mediated, lifelong disease characterized by constant infiltration of the CNS by inflammatory cells, causing the formation of demyelinating lesions(A, 2004). One of the primary mechanisms causing demyelination is the false recruitment of CD4 T cells against myelin basic protein (MBP) that along with other immune cells penetrate the CNS and spark damage of the myelin sheath and neuronal loss(H and M, 2017). The clinical manifestations of MS vary from sensory deficits to defective motor control, most often leading to long-term disability.